I often report about the health benefits of taking regular, old aspirin—including added protection against cardiovascular disease and colon cancer.
And now, a brand-new study published in the prestigious New England Journal of Medicine has found it even reduces the risk of a rare, but aggressive type of cancer that, in recent years in the U.S., has increased in prevalence by an alarming 43 percent.
I’ll tell you more about that important study in a moment. But first, let’s talk a bit about the history of aspirin’s safe use…
Long history of safe use reducing pain and inflammation
Aspirin is an over-the-counter (OTC), non-steroidal anti-inflammatory drug (NSAID). And it’s been used safely by millions of Americans for more than a century. In fact, it first entered the U.S. market as a drug in 1898—eight years before the forerunner of the U.S. Food and Drug Administration (FDA) even existed. Then, the FDA “grandfathered” it in as an “existing” drug in 1938 because of its long history as a safe, effective medication.
Aspirin is used primarily as a pain reliever. And it actually derives from two traditional botanical remedies—white willow bark and meadowsweet grass.
Millions of Americans also take daily, low doses (80 mg) of aspirin to prevent heart attacks and strokes. Its anticoagulant effects reduce the risk of blood clots, which are typically the final step in the chain of events that lead to heart attacks and strokes.
Plus, it’s certainly a lot safer and less costly than the prescription drugs doled out by the mainstream to reduce the risk of blood clots in the millions of people with cardiovascular diseases and heart abnormalities.
Now, I should note that aspirin can increase bleeding risk—primarily in people with a family history. And overall, that risk appears to be very low, if you take it as directed.
So, with all of this in mind, let’s get back to the new research on aspirin and cancer that I mentioned at the beginning of this Dispatch…
Liver cancer rose by 43 percent between 2000 and 2016
Previous studies have shown that aspirin reduces the risk of colon cancer—probably due to its anti-inflammatory effects. And now, the new study has found that aspirin also reduces your risk for developing another deadly, gastro-intestinal cancer…
Hepatic (liver) cancer.
Granted, hepatic cancer rates are lower in the U.S. when compared to many other countries, particularly Africa and Asia.
But, as I mentioned earlier, the incidence of hepatic cancer in the U.S. has been skyrocketing in recent years. In fact, between 2000 and 2016, it rose by a staggering 43 percent.
Most experts believe this dramatic increase relates to the increasing rates of hepatitis C. (People with chronic hepatitis B or C run a greater risk of getting hepatic cancer.) And that makes a lot of sense…
As researched by Nobel laureate Baruch Blumberg, my faculty mentor at Penn, hepatitis starts as a virus that attacks the liver. Then, the virus can actually get into liver cells and alter them, so that they become cancerous. (We also did a study in China during the late 1980s to reduce the risk of cancer in people with hepatitis using selenium supplements.)
For the new study, researchers from Harvard Medical School looked specifically at the effect of daily aspirin on hepatic cancer risk and death rates in more than 64,000 people with chronic, viral hepatitis.
More than 14,000 were taking daily, low-dose aspirin to reduce their risk of heart attack and stroke. And more than 50,000 of them were not taking daily, low-dose aspirin.
Overall, the researchers found that taking daily, low-dose aspirin cut the incidence of deadly hepatic cancer in participants by more than 50 percent.
Among people with chronic hepatitis, only 4 percent of those who were taking aspirin developed hepatic cancer over a 10-year period. On the other hand, 8.3 percent of those with chronic hepatitis not taking aspirin got cancer. (That’s more than double the number of cancers!)
Overall, people with chronic hepatitis who took aspirin had a 31 percent lower risk of developing hepatic cancer. Furthermore, the longer someone took aspirin, the lower their risk. And someone who took aspirin for five or more years had as much as a 43 percent lower risk compared to someone who didn’t take aspirin.
Daily aspirin also seemed to improve death rates due to liver problems…
In fact, over a 10-year period, those who took daily aspirin had an 11 percent lower risk of dying from hepatic disease. Whereas over the same time period, those who didn’t take daily aspirin had an 18 percent risk of dying from liver problems.
The study also examined aspirin’s well-known, but rare bleeding risk. It turns out, the risk of bleeding was similar among both those taking aspirin and not taking it (about 7 to 8 percent for both groups).
Bottom line?
Talk to your doctor about whether taking aspirin is right for you. Especially if you have hepatitis B or C.
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Source:
“Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality,” New England Journal of Medicine, 2020. 382:1018-1028. doi.org:10.1056/NEJMoa1912035